CANTON — Adjusting with changes has helped the Medicine Center Pharmacy keep going for 45 years.

Paul White had worked 10 years with the former Schuman Drug when he decided, with his wife Susan, to open Canton’s first Medicine Shoppe Pharmacy franchise in 1976. The Whites opted out of the franchise in the late 1980s and renamed the store Medicine Center.

They haven’t looked back.

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Medicine Center has expanded to Louisville, Minerva and New Philadelphia. The company added an accredited non-sterile compounding laboratory in 2006 and opened an institutional pharmacy in 2010. A retail store — Half Off and Hot Buys — opened in Louisville in 2000.